The crash took place in Dutchess County at 4:30 p.m. Thursday, Aug. 11 in East Fishkill just north of Robinson Lane and Lake Walton Road.
When officers arrived, there was a black Dodge Ram and a blue BMW in the southbound lane, both with significant damage and one driver with serious injuries, said the East Fishkill Police.
The driver of the BMW, a 64-year-old Poughkeepsie man, was transported to MidHudson Regional Hospital where he died from his injuries, police said.
Police said a preliminary investigation revealed that a Dodge Ram, driven by a 16-year-old male resident of Wappingers Falls, was traveling northbound on Route 376 when the head-on collision occurred in the southbound lane.
The name of the victim has not been released pending notification to the family.
The investigation is continuing.
Witnesses are asked to contact 845-221-2111 and request to speak with Sgt. Humphreys or Detective Doughty.
"We extend our sincere condolences to the victim and the family," the department said.
This is a developing story. Check back to Daily Voice for updates.
Click here to follow Daily Voice Hudson and receive free news updates.